This report presents an overview of the drug phenomenon in Luxembourg, covering drug policy, drug supply and demand, prevalence and patterns in drug use, drug use in prison, health consequences and responses, as well as drug markets and crime. The statistical data and analysis presented in this report refer to 2021 or the most recent year for which data are available and were provided to the Luxembourg Focal Point of the EMCDDA (PFLDT) from routine monitoring by the RELIS network, unless stated otherwise.